Spondyloarthritis & psoriatic arthritis
Psoriatic arthritis flare incidence, definition and risk factors: a systematic review
Authors' conclusion
The current prevalence of flare ranged between 7% and 10%, and the annual incidence was 22-23%, based on high-quality scoring.
Study context
- Population
- Original articles studying PsA flare (cohort, cross-sectional and clinical trial designs); Embase, Medline ALL, Web of Science Core Collection and Cochrane Central searched until September 2023
- Participants
- 54 studies
- Outcome
- Incidence of PsA flare, criteria used to define it and associated risk factors
Methodological detailsNewcastle-Ottawa scale quality assessment
- Newcastle-Ottawa scale quality assessment
Pooled result
As reported in the abstract
PsA flare prevalence and incidence
- Prevalence of current flare (n = 8 studies)
- 7% and 50%
- Incidence over 6 months (n = 3 studies)
- 10% and 27%
- Incidence over 12 months (n = 2 studies)
- 22% and 23%
- Current patient-reported flare, high-quality scoring (n = 1)
- 10%
- Current physician-reported flare, high-quality scoring
- 7%
- Incidence rate over 12 months, physician-reported, high-quality scoring (n = 2)
- 22-23%
Further pooled results
Criteria used in flare definition (44 studies; seven categories)
- Disease activity scores
- 36%
- Patient-reported flare
- 39%
- Physician-reported flare
- 30%
- Change in therapy
- 25%
Risk factors (28 studies; four categories: arthritis therapies, SARS-CoV, PsA features, other)
- The factors showed limited or unclear evidence
Original publication
Psoriatic arthritis flare incidence, definition and risk factors: a systematic review. Rheumatology (Oxford). Published 20 May 2025. doi:10.
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