Spondyloarthritis & psoriatic arthritis
Insights into suicidal behavior among psoriatic arthritis patients: A systematic review and a genetic linkage disequilibrium analysis
Authors' conclusion
Suicide behavior in PsA patients was associated with depression and other psychiatric comorbidities. Further evidence supports a genetic origin, at least partly.
Study context
- Population
- PsA patients; full-text original articles describing suicidal behavior in PsA (PubMed/Medline, Web of Science, EMBASE, inception to May 2022)6 articles
- Participants
- 122,160 patients
- Outcome
- Magnitude of suicidal behavior among PsA patients
Methodological detailsPRISMA guidelines, genome-wide association study (GWAS) catalog analysis
- PRISMA guidelines
- GWAS catalog analysis
Pooled result
As reported in the abstract
Suicidal ideation among 13,899 PsA patients: 74
0.53%
Suicide attempts among 13,899 PsA patients: 125
0.9%
Complete suicides among 17,383 patients (2 studies): 13
0.07%
Female among PsA patients with suicidal behaviour
64%
Further pooled results
Suicidal ideation and suicide attempts (13,899 PsA patients)
- Suicidal ideation
- 74 (0.53%)
- Suicide attempts
- 125 (0.9%)
Complete suicides (two studies, 17,383 patients)
- Complete suicides
- 13 (0.07%)
Shared genetic haplotype for PsA and depression
- Haplotype on chromosomal region 6p21.1 (29,597,596 to 32,251,264 Mb) contains predisposing single nucleotide polymorphisms (SNPs) for PsA and depression
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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