Spondyloarthritis & psoriatic arthritis
Association of clinical and sonographic factors with discrepancy between patients’ and evaluators’ global assessments in psoriatic arthritis
Authors' conclusion
The discrepancy between PGA and EGA in PsA is characterized by worse disease activity scores and worse subjective measures but not by sonographic measures.
Study context
- Population
- Consecutive psoriatic arthritis (PsA) patients (CASPAR criteria) with clinical examination, patient-reported outcomes (PROs) and ultrasound (US) (52 joints, 40 tendons, 14 entheses)
- Participants
- 158 patients
- Exposure
- Discordant vs concordant patients' global assessments (PGA)–evaluators' global assessments (EGA)
- Discordantn = 88
- Outcome
- Discordance between PGA and EGA (delta ≥3) and factors associated with it
Methodological detailsconsecutive recruitment, US assessor blinded to clinical data, EGA scored blinded to PGA, multivariate regression
- Consecutive recruitment
- US assessor blinded to clinical data
- EGA scored blinded to PGA
- Multivariate regression
Main finding
As reported in the abstract
PGA–EGA discordance
Discordant
55.7%
88
- Mean difference between PGA and EGA
- 3.3
- Higher tender joint counts (TJC) associated with greater discordance (multivariate), OR
- 1.07
- Lower swollen joint count associated with greater discordance (multivariate), OR
- 0.85
- Depression associated with greater discordance (multivariate), OR
- 1.05
Observational data: associations, not effects.
Further findings
Clinical features, discordant vs concordant
- Discordant had significantly higher TJC, enthesitis, C-reactive protein (CRP) and lower working status rates (P < 0.05)
- US scores similar between the groups
- Discordant had higher PsA activity scores, more fibromyalgia and worse PROs incl. pain, depression, fatigue and quality of life (P < 0.05)
Original publication
Association of clinical and sonographic factors with discrepancy between patients’ and evaluators’ global assessments in psoriatic arthritis. Rheumatology (Oxford). Published 19 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →