Spondyloarthritis & psoriatic arthritis
Sex-Based Differences in Sonographic and Clinical Findings Among Patients With Psoriatic Arthritis
Main finding · US scores, males vs femalesResult — go to the resultOdds ratio 1.96Authors' conclusion
Sonographic enthesitis was more prevalent in males compared to females with PsA. These differences were not reflected by enthesitis disease activity scores derived from clinical assessment.
Study context
- Population
- Consecutive prospectively recruited patients with PsA (CASPAR criteria) undergoing clinical examination and detailed greyscale and Doppler ultrasound (US) of 52 joints, 40 tendons and 14 entheses (MASEI plus lateral epicondyles)
- Participants
- 158 participants
- Exposure
- Male vs female patients with PsA
- Malesn = 70
- Femalesn = 88reference
- Outcome
- Sex-based differences in US scores (synovitis, tenosynovitis, enthesitis; enthesitis split into inflammatory and structural lesions)
Methodological detailsprospective consecutive recruitment, sonographer blinded to clinical data, multivariate ordinal logistic regression
- Prospective consecutive recruitment
- Sonographer blinded to clinical data
- Multivariate ordinal logistic regression
Main finding
US scores, males vs females
Odds ratio
1.96
P = 0.02
As reported in the abstract
- Hypoechogenicity, thickening and enthesophytes more prevalent in males than females
- P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Clinical characteristics by sexMales vs Females · higher employment rate in males | P = 0.01 |
| Clinical characteristics by sexMales vs Females · higher PASI in males | P = 0.04 |
| Clinical characteristics by sexMales vs Females · higher mean swollen joint count in males | P = 0.04 |
Original publication
Sex-Based Differences in Sonographic and Clinical Findings Among Patients With Psoriatic Arthritis. J Rheumatol. Published 15 October 2022. doi:10.
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