Spondyloarthritis & psoriatic arthritis
Sex-Specific Differences in Patients With Psoriatic Arthritis: A Systematic Review
Authors' conclusion
This review indicates that important differences exist between the sexes in PsA.
Study context
- Population
- Adults with psoriatic arthritis (PsA) in observational studies reporting outcomes by sex (published January 1, 2015, to November 13, 2020)27 studies (31 publications)
- Comparison
- Women vs men with PsA
- Outcome
- Sex-specific differences in clinical characteristics, disease activity, PROs and treatment response
Methodological detailsobservational studies, studies with 100 or more patients prespecifying a comparison by sex, Searches of MEDLINE, Embase and the Cochrane Database of Systematic Reviews in November 2020, plus hand searches, ClinicalTrials.gov and congress abstracts; 3283 unique records
- Observational studies
- Studies with 100 or more patients prespecifying a comparison by sex
- Searches of MEDLINE, Embase and the Cochrane Database of Systematic Reviews in November 2020, plus hand searches, ClinicalTrials.gov and congress abstracts; 3283 unique records
Pooled result
As reported in the abstract
- Generally higher rates of peripheral disease in women, including higher tender joint counts
- Some evidence of more axial disease in men, plus greater skin disease burden
- Consistently no differences in Dermatology Life Quality Index scores
- Across other patient-reported outcomes (PROs), women had worse scores, including pain and fatigue
- Women had poorer responses to treatment (e.g. American College of Rheumatology (ACR) responses, minimal disease activity)
Original publication
Sex-Specific Differences in Patients With Psoriatic Arthritis: A Systematic Review. J Rheumatol. Published 15 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →