Spondyloarthritis & psoriatic arthritis
Work productivity in patients with axial spondyloarthritis initiating biological or targeted synthetic disease-modifying antirheumatic drugs: a systematic literature review and meta-analysis
Authors' conclusion
Over 50% of employed patients with active axSpA experienced work impairment, primarily due to presenteeism. Overall work productivity improved at Weeks 12-16 to a greater extent for patients who received b/tsDMARDs than placebo. Work productivity loss was associated with a substantial cost burden, which was reduced with improvements in impairment.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) initiating b/tsDMARDs, studies reporting Work Productivity and Activity Impairment (WPAI), published 1 January 2010 to 21 October 202111 studies
- Participants
- 994 vs 727
- Comparison
- b/tsDMARDs vs placebo
- b/tsDMARDsn = 994
- Placebon = 727reference
- Outcome
- Absolute mean change from baseline in WPAI domains (overall work productivity, absenteeism, presenteeism, activity impairment)
- Follow-up
- Week 12-16
Methodological detailsrandom-effects meta-analysis
- Random-effects meta-analysis
Pooled result
As reported in the abstract
Overall work impairment, pooled mean change from baseline
b/tsDMARDs
−21.6%
mean
Placebo
−12.3%
mean
Further pooled results
Baseline WPAI scores in working patients initiating b/tsDMARD · mean Baseline
- Mean overall work productivity impairment (N=7 studies)
- 52.1%
- Mean absenteeism (N=6 studies)
- 11.0%
- Mean presenteeism (N=6 studies)
- 48.8%
Potential annual reduction in cost of paid and unpaid productivity loss per patient (extrapolated to 1 year)
- Range
- €11 962.88 to €14 293.54
- Extrapolated
Original publication
Work productivity in patients with axial spondyloarthritis initiating biological or targeted synthetic disease-modifying antirheumatic drugs: a systematic literature review and meta-analysis. RMD Open. Published 30 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →