Spondyloarthritis & psoriatic arthritis
Improvement in work productivity among psoriatic arthritis patients treated with biologic or targeted synthetic drugs: a systematic literature review and meta-analysis
Authors' conclusion
Substantial improvements across various WPAI domains were noted after 24 weeks of b/tsDMARD treatment, especially in presenteeism, total work productivity, and activity impairment.
Study context
- Population
- Patients with psoriatic arthritis (PsA) treated with b/tsDMARDs (adalimumab, bimekizumab, guselkumab, ixekizumab, risankizumab, secukinumab or upadacitinib); studies published January 1, 2010-October 22, 2021
- Participants
- 3,741 patients12 studies
- Comparison
- Work Productivity and Activity Impairment (WPAI) domains at baseline vs ≈24 weeks of b/tsDMARD treatment
- Outcome
- Overall absolute mean change from baseline in each WPAI domain (absenteeism, presenteeism, total work productivity, activity impairment)
- Follow-up
- Week 24
Methodological detailsrandom effects meta-analysis of single means, before/after comparison without adjustment for placebo response
- Random effects meta-analysis of single means
- Before/after comparison without adjustment for placebo response
Pooled result
As reported in the abstract
Absolute mean improvement from baseline in WPAI domains
- Absenteeism, absolute mean improvement
- 2.4 percentage points (95% CI 0.6, 4.1)
- Presenteeism, absolute mean improvement
- 17.8%p (95% CI 16.2,19.3)
- Total work productivity impairment, absolute mean improvement
- 17.6%p (95% CI 15.9,19.4)
- Activity impairment, absolute mean improvement
- 19.3%p (95% CI 17.6, 21.0)
- Total work productivity, mean relative improvement
- 41%
Further pooled results
Overall mean baseline WPAI scores
- Absenteeism
- 11.4%
- Presenteeism
- 38.7%
- Total work productivity impairment
- 42.7%
- Activity impairment
- 48.9%
Change in work outcomes across b/tsDMARDs
- The change in work outcomes in the b/tsDMARDs appeared similar
Original publication
Improvement in work productivity among psoriatic arthritis patients treated with biologic or targeted synthetic drugs: a systematic literature review and meta-analysis. Arthritis Res Ther. Published 15 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →