Spondyloarthritis & psoriatic arthritis
Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography
Authors' conclusion
MSOT allows determination of distinct metabolic differences between arthritis and enthesitis in a non-invasive setting in humans in vivo.
Study context
- Population
- Patients with RA or PsA and healthy controls; MSOT of MCP and wrist joints and entheses (lateral humeral epicondyle common extensor, patellar, quadriceps and Achilles tendons)1,535 MSOT and 982 US scans
- Participants
- 87 patients
- Exposure
- Affected vs unaffected joints and entheses, measured by MSOT
- PsAn = 34
- RAn = 17
- Healthy controls (HCs)n = 36reference
- Outcome
- MSOT-measured Hb, oxygen saturation, collagen and lipid levels; scaled mean differences between affected and unaffected joints and entheses
Methodological detailslinear mixed effects models
- Linear mixed effects models
Main finding
As reported in the abstract
- Entheseal tenderness: no significant metabolic changes
- Enthesitis-related sonographic changes: increased total haemoglobin (Hb), oxygen saturation and collagen content
- Arthritis-related clinical and sonographic findings: increased Hb, reduced oxygen saturation and reduced collagen content
- Synovial hypertrophy: increased lipid content in the joints
Observational data: associations, not effects.
Original publication
Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography. Rheumatology (Oxford). Published 14 June 2022. doi:10.
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