Spondyloarthritis & psoriatic arthritis
Unveiling Metabolic Similarities of Entheses in Patients with Psoriasis and Psoriatic Arthritis Using Noninvasive In Vivo Molecular Imaging: Results From a Cross‐sectional Exploratory Study
Authors' conclusion
Patients with PsA and PsO exhibit an analogous metabolic pattern at the entheses that is exacerbated in the presence of inflammation.
Study context
- Population
- bDMARD-naïve patients with psoriatic arthritis (PsA) and PsO and healthy controls (HCs); six entheses (lateral humeral epicondyle, distal patellar tendon and Achilles tendon attachments) examined clinically, by US and by multispectral optoacoustic tomography (MSOT)540 entheses
- Participants
- 90 patients
- Exposure
- PsA and PsO vs HCs
- PsAn = 30
- PsOn = 30
- HCsn = 30reference
- Outcome
- MSOT-measured hemoglobin (Hb), SO2, collagen and lipid levels at the entheses, mean differences between groups
Methodological detailsexploratory, linear mixed effects models
- Exploratory
- Linear mixed effects models
Main finding
As reported in the abstract
MSOT-measured analytes at the entheses vs HCs
- More pronounced changes in PsA
- PsA vs HCs: P = 0.003
- PsO vs HCs: P = 0.054
- PsA vs HCs: P < 0.001
- PsO vs HCs: P = 0.001
- PsA vs HCs: P < 0.001
- PsO vs HCs: P < 0.001
Observational data: associations, not effects.
Further findings
MSOT analytes in tender vs nontender entheses
- Significantly lower collagen levels in tender entheses
- P = 0.01
- Increased lipids in tender entheses
- P = 0.03
MSOT analytes and US anomalies
- Erosions on US associated with significant differences in saturation (SO2)
- P = 0.014
- Enthesophytes on US associated with significant differences in lipid signals
- P = 0.020
Original publication
Unveiling Metabolic Similarities of Entheses in Patients with Psoriasis and Psoriatic Arthritis Using Noninvasive In Vivo Molecular Imaging: Results From a Cross‐sectional Exploratory Study. Arthritis Rheumatol. Published 8 July 2024. doi:10.
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