Spondyloarthritis & psoriatic arthritis
Association between musculoskeletal sonographic features and response to treatment in patients with psoriatic arthritis
Authors' conclusion
The study results provide preliminary evidence supporting the utility of musculoskeletal ultrasound in predicting treatment response and drug persistence in PsA.
Study context
- Population
- Patients with active psoriatic arthritis (PsA) starting therapy; baseline US of 64 joints, 28 tendons and 16 entheses135 treatment periods
- Participants
- 107 patients
- Outcome
- Association of baseline sonographic scores with DAPSA change and drug persistence
- Follow-up
- 3-6 months after initiating therapy
Methodological detailsCox proportional hazards models, generalised estimating equation models
- Cox proportional hazards models
- Generalised estimating equation models
Main finding
As reported in the abstract
Higher baseline synovitis score, greater DAPSA reduction (β)
−3.89
Higher baseline peritenonitis score, greater DAPSA reduction (β)
−3.93
Higher baseline enthesitis structural score, greater DAPSA reduction (β)
−2.91
Total inflammatory score independently predicted DAPSA change, regardless of total structural damage score (β)
−5.23
Observational data: associations, not effects.
Further findings
Drug persistence: higher sonographic erosion score and earlier drug discontinuation
| aHR (95% CI) | ||
|---|---|---|
| Higher sonographic erosion score | 1.28 (1.03–1.61) | |
| 0.512Adjusted hazard ratio (log scale) |
- Drug persistence: higher sonographic erosion score and earlier drug discontinuation: 105 treatment periods analysed
Original publication
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