Spondyloarthritis & psoriatic arthritis
Performance of an MRI scoring system for inflammation of joints and entheses in peripheral SpA: post-hoc analysis of the CRESPA trial
Authors' conclusion
The proposed MRI lower-extremity inflammation index demonstrated reliability, validity, and sensitivity to change in patients with early pSpA.
Study context
- Population
- Patients with early peripheral SpA (pSpA) starting the TNFi golimumab; MRI of pelvis and lower extremities46 with repeat MRI
- Participants
- 56 patients
- Primary endpoint
- Reliability, validity and sensitivity to change of a novel semi-quantitative MRI lower-extremity inflammation index (75 sites, each 0-3)
Methodological detailspost-hoc analysis, Three readers; four lesion types: entheseal osteitis, entheseal soft-tissue inflammation, joint osteitis, joint synovitis/effusion
- Post-hoc analysis
- Three readers; four lesion types: entheseal osteitis, entheseal soft-tissue inflammation, joint osteitis, joint synovitis/effusion
Primary result
As reported in the abstract
MRI lower-extremity inflammation index: change, reliability and validity · after 24, 36 or 48 weeks (sustained clinical remission)
- MRI index decreased
- 34 of 46 patients (74%)
- MRI response (decrease above smallest detectable change (SDC) of 2.8)
- 15 (33%)
- Interreader reliability, average-measure ICC, status scores
- 0.92 (95% CI: 0.85-0.95)
- Interreader reliability, average-measure ICC, change in scores
- 0.89 (0.80-0.94)
- Correlation with CRP, Spearman's rho
- 0.41 (0.23-0.56)
- Correlation with swollen joint count of 6 joints
- 0.47 (0.27-0.63)
- Correlation with tender enthesis count of 14 entheses
- 0.32 (0.12-0.50)
- Correlation with pain score
- 0.28 (0.08-0.46)
Further findings
MRI response in patients with clinical involvement of MRI-assessed lower-extremity sites (subgroup)
- MRI response
- 13 of 28 (46%)
Original publication
Performance of an MRI scoring system for inflammation of joints and entheses in peripheral SpA: post-hoc analysis of the CRESPA trial. Rheumatology (Oxford). Published 6 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →