Spondyloarthritis & psoriatic arthritis
Why Do Some Patients Have Severe Sacroiliac Disease But No Syndesmophytes in Ankylosing Spondylitis? Data From a Nested Case-Control Study
Authors' conclusion
Using CART analysis and univariable modeling, women were less likely to have syndesmophytes despite advanced disease duration and SI joint disease. Patients with younger age of symptom onset were less likely to have syndesmophytes.
Study context
- Population
- Patients with ankylosing spondylitis (AS) from the Prospective Study of Outcomes in AS (PSOAS) cohort with disease duration ≥ 20 years and fused sacroiliac (SI) joints
- Participants
- 354 patients
- Comparison
- AS patients with vs without syndesmophytes
- No syndesmophytesn = 23reference
- Outcome
- Risk factors for syndesmophyte presence
Methodological detailsClassification and regression tree (CART) analysis, univariable logistic regression
- CART analysis
- Univariable logistic regression
Main finding
As reported in the abstract
Factors associated with syndesmophyte presence
Odds ratio (95% CI)
Femalevs Maleunivariable; females less likely to have syndesmophytes
0.17(0.07–0.41)
Age of symptom onset > 16 yearsvs Age of symptom onset ≤ 16 yearsunivariable
2.72(1.15–6.45)
- All patients lacking syndesmophytes were HLA-B27 positive
- 23
Observational data: associations, not effects.
Original publication
Why Do Some Patients Have Severe Sacroiliac Disease But No Syndesmophytes in Ankylosing Spondylitis? Data From a Nested Case-Control Study. J Rheumatol. Published 1 October 2022. doi:10.
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