Spondyloarthritis & psoriatic arthritis
Examining the Interchangeability of Two Different Patient‐Reported Global Assessment Measures in an Observational Axial Spondyloarthritis Cohort
Authors' conclusion
Prior measures of PGA used before the validation of ASDAS are a valid substitution for the PGA in the ASDAS based on calculation of a κ coefficient showing excellent agreement.
Study context
- Population
- Patients with axSpA in the Prospective Study of Outcomes in Ankylosing Spondylitis (PSOAS) observational cohort
- Participants
- 610 unique patient visits
- Exposure
- AxSpA Disease Activity Score (ASDAS) calculated with PSOAS-PGA vs ASDAS calculated with standard ASDAS-PGA
- Outcome
- Agreement of ASDAS disease activity categories calculated with PSOAS-PGA vs ASDAS-PGA (weighted Cohen's κ)
Methodological detailsobservational cohort, weighted Cohen's κ, intraclass correlation coefficients (two-way mixed-effects model)
- Observational cohort
- Weighted Cohen's κ
- Intraclass correlation coefficients (two-way mixed-effects model)
Main finding
As reported in the abstract
Agreement of ASDAS disease activity categories
Proportion of agreement
86.7%
Cohen's κ coefficient
0.818
Observational data: associations, not effects.
Further findings
Agreement of older vs newer global single-item scores (ICC, two-way mixed-effects model)
- ICC
- 0.980
- Consistent with excellent agreement
Original publication
Examining the Interchangeability of Two Different Patient‐Reported Global Assessment Measures in an Observational Axial Spondyloarthritis Cohort. Arthritis Care Res (Hoboken). Published 14 September 2026. doi:10.
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