Spondyloarthritis & psoriatic arthritis
Incidence, baseline-associated factors and burden of difficult-to-manage axial spondyloarthritis: a 10-year analysis of the DESIR cohort
Authors' conclusion
In this recent-onset axSpA inception cohort with long-term follow-up, D2M-axSpA was rare, rarely associated with true treatment refractoriness or structural progression and was accompanied by a persistent disease burden carrying a substantial socio-economic impact
Study context
- Population
- Patients from the French prospective DESIR cohort fulfilling ASAS 2009 criteria for axSpA and exposed to ≥1 biologic disease-modifying antirheumatic drug (bDMARD)exposed to ≥1 bDMARD
- Participants
- 177 patients
- Exposure
- Difficult-to-manage axial spondyloarthritis (D2M-axSpA) vs no D2M-axSpA for long-term outcomes
- Outcome
- Cumulative incidence of D2M-axSpA and TR-axSpA
- Follow-up
- Up to 10 years
Methodological detailsinception cohort, recent-onset axSpA, up to 10 years of follow-up, Cox proportional hazards models
- Inception cohort
- Recent-onset axSpA
- Up to 10 years of follow-up
- Cox proportional hazards models
Main finding
As reported in the abstract
D2M-axSpA, ASAS definition
6.8%
95% CI 2.4 to 11.0
D2M-axSpA, extended definition
14.4%
95% CI 8.3 to 20.2
TR-axSpA, ASAS definition
0.7%
TR-axSpA, extended definition
3.7%
Observational data: associations, not effects.
Further findings
Fibromyalgia prevalence during follow-up (extended definition)
Opioid use (extended definition)
| Outcome | D2M-axSpA | No D2M-axSpA |
|---|---|---|
| Cumulative number of medical visits (extended definition) | 110 | 60 |
Baseline factors associated with D2M-axSpA (extended definition)
- Female sex and higher baseline disease activity associated with development of D2M-axSpA
Original publication
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