Spondyloarthritis & psoriatic arthritis
Erosions on T1-Weighted Magnetic Resonance Imaging Versus Radiography of Sacroiliac Joints in Recent-Onset Axial Spondyloarthritis: 2-Year Data (EMBARK Trial and DESIR Cohort)
Authors' conclusion
In recent-onset axSpA, SIJ erosions and erosion change were observed more frequently on MRI than radiography.
Study context
- Population
- Recent-onset axial spondyloarthritis (axSpA)224 at baseline
- Comparison
- Detection of sacroiliac joint (SIJ) erosions and change in erosions over 104 weeks: Magnetic resonance imaging (MRI) vs radiographs
- Primary endpoint
- Detection of SIJ erosions and baseline-to-week 104 change in erosions, MRI vs radiographs
- Follow-up
- Week 104
Methodological detailssecondary analysis of the EMBARK trial and DESIR cohort, 3 MRI readers and 3 different radiograph readers, consensus of ≥ 2 of 3 readers
- Secondary analysis of the EMBARK trial and DESIR cohort
- 3 MRI readers and 3 different radiograph readers
- Consensus of ≥ 2 of 3 readers
Primary result
As reported in the abstract
Discordant erosion detection at baseline
MRI erosions without radiographic erosions
48 of 224
21.4%
Radiographic erosions without MRI erosions
14 of 224
6.3%
Further findings
| Outcome | P value |
|---|---|
| Decrease in erosions on one method but not the other · 104 weeks | P < 0.001 |
- Decrease in erosions on one method but not the other — Decrease on MRI but not radiographs
- 49/221 (22.2%)
- Decrease in erosions on one method but not the other — Decrease on radiographs but not MRI
- 6/221 (2.7%)
Treatment-discriminant capacity (largest standardised differences), unadjusted/adjusted Hedges G · week 104
- Change in SPARCC MRI erosion discrete score
- 0.40/0.50
- Change in erosion average score
- 0.40/0.56
- Meeting modified New York criteria on radiographs
- 0.40/0.43
- Etanercept vs control cohorts
Original publication
Erosions on T1-Weighted Magnetic Resonance Imaging Versus Radiography of Sacroiliac Joints in Recent-Onset Axial Spondyloarthritis: 2-Year Data (EMBARK Trial and DESIR Cohort). J Rheumatol. Published 15 February 2024. doi:10.
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