Spondyloarthritis & psoriatic arthritis
Sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up. Data from the DESIR cohort
Authors' conclusion
MRI structural outcomes in the SIJ (ie, fatty lesions) are more sensitive to change than radiographic outcomes. Conversely, the mSASSS remains the most sensitive method, even when compared with MRI of the spine.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) from the DESIR cohort; Sacroiliac joints (SIJ) and spine radiographs and MRIs at baseline and 1, 2, 5 and 10 years46% males, mean age 33.6 years
- Participants
- 659 patients
- Outcome
- Sensitivity to change (relative standardised yearly rate of change) of structural imaging outcomes
- Follow-up
- 10 years
Methodological detailsgeneralised estimating equation models, standardised rate of change
- Generalised estimating equation models
- Standardised rate of change
Main finding
As reported in the abstract
Relative standardised rate of change per year
SIJ: most sensitive outcome (MRI and radiographs) was ≥3 fatty lesions at a specific timepoint, vs modified New York criteria as reference
5.28
Spine: most sensitive outcome (MRI and radiographs) was modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS), vs ≥1 syndesmophyte as reference
1.76
Observational data: associations, not effects.
Original publication
Sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up. Data from the DESIR cohort. RMD Open. Published 25 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →