Spondyloarthritis & psoriatic arthritis
Plasma Proteomics Identifies Molecular Signatures and Biomarkers Associated With High Structural Damage in Ankylosing Spondylitis
Authors' conclusion
This study supports a dual-pathway model in which SAA2-marked systemic inflammation and ITGA2B-associated platelet-extracellular matrix remodeling appear partially dissociated yet remain biologically interconnected in AS.
Study context
- Population
- Patients with ankylosing spondylitis (AS) stratified by structural damage, and normal controlsdiscovery cohort
- Participants
- 88 patients
- Comparison
- AS with high vs low structural damage vs normal controls
- High structural damagen = 25
- Low structural damagen = 31
- Normal controlsn = 32reference
- Outcome
- Plasma protein signatures associated with structural damage severity in AS
Methodological detailsdiscovery and validation cohorts, prospective discovery cohort, independent validation cohort, age- and sex-adjusted differential expression analysis, weighted gene coexpression network analysis (WGCNA), integrated machine learning, ELISA validation
- Discovery and validation cohorts
- Prospective discovery cohort
- Independent validation cohort
- Age- and sex-adjusted differential expression analysis
- WGCNA
- Integrated machine learning
- ELISA validation
Performance
As reported in the abstract
Plasma proteomic signatures of structural damage
Differentially expressed proteins, high structural damage vs normal controls
536
Combined model AUC, validation cohort
0.917
Individual biomarker AUCs (combined model significantly better; all Holm-adjusted P < 0.05)
0.732-0.819
Original publication
Plasma Proteomics Identifies Molecular Signatures and Biomarkers Associated With High Structural Damage in Ankylosing Spondylitis. Arthritis Rheumatol. Published 28 September 2026. doi:10.
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