Spondyloarthritis & psoriatic arthritis
Single-cell profiling reveals senescent bone marrow mesenchymal stem cell subpopulations driving pathological ossification in ankylosing spondylitis
Authors' conclusion
This study identifies a senescence-associated, hypermetabolic BMSC subpopulation that is closely associated with structural progression in AS, providing a cellular basis for pathological bone formation
Study context
- Population
- BMSCs from patients with ankylosing spondylitis (AS)47,628 cells analysed
- Participants
- 12 participants
- Comparison
- Severe structural damage vs no structural damage
- Severe structural damage (SSD)n = 9
- No structural damage (NSD)n = 3reference
- Outcome
- BMSC subpopulations
Methodological detailssingle-cell RNA sequencing, trajectory inference, metabolic profiling, pathway enrichment, in silico drug screening
- Single-cell RNA sequencing
- Trajectory inference
- Metabolic profiling
- Pathway enrichment
- In silico drug screening
Main finding
As reported in the abstract
- Eight BMSC subpopulations forming a continuum from progenitors to lineage-committed cells
- eight
Original publication
Single-cell profiling reveals senescent bone marrow mesenchymal stem cell subpopulations driving pathological ossification in ankylosing spondylitis. Rheumatology (Oxford). Published 24 August 2026. doi:10.
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