Spondyloarthritis & psoriatic arthritis
Distinct spondyloarthritis phenotypes and disease burden in patients with concomitant hidradenitis suppurativa
Authors' conclusion
Concomitant SpA and HS appears to be associated with a distinct clinical phenotype and higher disease burden that translates into greater therapeutic complexity and healthcare utilization.
Study context
- Population
- Adults with spondyloarthritis (SpA), with or without dermatologist-confirmed hidradenitis suppurativa; data from the preceding three years from electronic medical records
- Participants
- 39 vs 111
- Comparison
- SpA with concomitant hidradenitis suppurativa (HS) vs SpA without HS
- Casesn = 39
- Controlsn = 111reference
- Outcome
- Clinical phenotype and disease burden
Methodological detailsmulticentre, Data from the preceding three years extracted from electronic medical records
- Multicentre
- Data from the preceding three years extracted from electronic medical records
Main finding
As reported in the abstract
Clinical phenotype, axSpA+HS vs controls
- HLA-B27 positivity, axial SpA (axSpA)+HS vs controls
- 46%vs. 79%, p = 0.002
- Radiographic sacroiliitis, axSpA+HS vs controls
- 60%vs. 86%, p = 0.007
- Arthritis, axSpA+HS vs controls
- 40%vs. 23%; p = 0.081
- ASDAS-CRP, axSpA+HS vs controls
- 3.0 vs. 2.1, p = 0.003
- CRP (mg/L), axSpA+HS vs controls
- 11.3 vs. 3.3 mg/L, p = 0.001
Observational data: associations, not effects.
Further findings
Comorbidities, axSpA+HS vs controls
- Active smoking
- 68%vs. 35%; p = 0.006
- Hypertension
- 44%vs. 17%; p = 0.011
- Anxiety-depressive disorders
- 36%vs. 16%; p = 0.046
- IBD (extra-musculoskeletal manifestation)
- 20%vs. 3%; p = 0.020
Treatment and healthcare use, axSpA+HS vs controls
- Greater number of different biologic agents received
- P = 0.028
- csDMARD use
- 52%vs. 28%; p = 0.018
- Rheumatology visits (median)
- median 9.0 vs. 7.0; p = 0.050
Original publication
Distinct spondyloarthritis phenotypes and disease burden in patients with concomitant hidradenitis suppurativa. Semin Arthritis Rheum. Published 19 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →