Spondyloarthritis & psoriatic arthritis
Entheseal structural damage according to OMERACT definitions unveils distinct ultrasound phenotypes in spondyloarthritis (SpA): findings from the DEUS multicentre study
Authors' conclusion
This study reveals a high prevalence of ultrasound-detected structural damage at the enthesis and identifies distinct SpA phenotypes based on these findings.
Study context
- Population
- Patients with SpA, 20 rheumatology centres (DEUS study); US of large lower limb entheses
- Participants
- 413 SpA patients
- Exposure
- Axial spondyloarthritis (axSpA) vs psoriatic arthritis (PsA)
- axSpAn = 224
- PsAn = 189
- Outcome
- Prevalence and distribution of US-detected entheseal structural lesions (bone erosions, enthesophytes, calcifications; OMERACT definitions)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Prevalence of entheseal structural lesions in SpA
Enthesophytes (most common lesion)
78.7 %
Calcifications
43.6 %
Bone erosions
24.9 %
Observational data: associations, not effects.
Further findings
Enthesophytes, PsA vs axSpA
P < 0.001
Erosions and calcifications, PsA vs axSpA
- No significant differences in erosions and calcifications
Factors associated with lesions (multivariate logistic regression)
- Erosions associated with inflammatory markers, HLA-B27 positivity, clinical enthesitis and longer disease duration
- Enthesophytes linked to PsA, psoriasis, clinical enthesitis and longer disease duration
- Calcifications associated with hypertension, metabolic syndrome and obesity
- All lesions associated with bDMARD use
Original publication
Entheseal structural damage according to OMERACT definitions unveils distinct ultrasound phenotypes in SpA: findings from the DEUS multicentre study. Semin Arthritis Rheum. Published 28 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →