Spondyloarthritis & psoriatic arthritis
Power Doppler signal at the enthesis and bone erosions are the most discriminative OMERACT ultrasound lesions for spondyloarthritis (SpA): results from the DEUS (Defining Enthesitis on Ultrasound in Spondyloarthritis) multicentre study
Authors' conclusion
Ultrasound could differentiate between SpA-related enthesitis and other forms of entheseal pathology (ie, mechanical enthesitis), thus improving the assessment of entheseal involvement in SpA.
Study context
- Population
- Patients with SpA and disease controls undergoing clinical and US examination of lower limb large entheses, 20 rheumatology centres
- Participants
- 413 vs 282
- Exposure
- SpA vs disease controls
- SpAn = 413
- Disease controlsn = 282reference
- Outcome
- Discriminative value of OMERACT US lesions of enthesitis for SpA
Methodological detailsmulticentre, 20 rheumatology centres
- Multicentre
- 20 rheumatology centres
Main finding
As reported in the abstract
Association of OMERACT US lesions with SpA (multivariate)
SpA vs Disease controlsOdds ratio (95% CI)P value
PD at enthesis
8.77(4.40–19.20)
P < 0.001Bone erosions
4.75(2.43–10.10)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Achilles tendon (only lower limb enthesis associated with SpA, multivariate) | 1.93 (1.30–2.88) | P < 0.001 | |
| Active enthesitis | 9.20 (4.21–23.20) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Active enthesitis
- Unlike individual OMERACT US lesions, consistently associated with most clinical measures of SpA disease activity and severity
Original publication
Power Doppler signal at the enthesis and bone erosions are the most discriminative OMERACT ultrasound lesions for SpA: results from the DEUS (Defining Enthesitis on Ultrasound in Spondyloarthritis) multicentre study. Ann Rheum Dis. Published 12 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →