Spondyloarthritis & psoriatic arthritis
Anatomical pattern of entheseal and synovial fibroblast activation in patients with psoriasis and its risk of developing psoriatic arthritis
Authors' conclusion
Patients with psoriasis presenting with arthralgia show localised signs of resident tissue activation in joints and entheses, which are associated with higher risk of developing PsA.
Study context
- Population
- Patients with psoriasis and arthralgia
- Participants
- 36 patients
- Outcome
- 68Ga-FAPI-04 uptake (activated fibroblasts) in joints and entheses
Methodological detailswhole-body 68Ga-FAPI-04-PET/CT, logistic regression, survival analyses
- Whole-body 68Ga-FAPI-04-PET/CT
- Logistic regression
- Survival analyses
Main finding
As reported in the abstract
- Participants with uptake
- 29 (80.6%)
- Joints with uptake
- 318 (7.9%)
- Entheses with uptake
- 369 (7.3%)
- Mean SUVmax (SD), joints
- 3.2 (1.8)
- Mean SUVmax (SD), entheses
- 2.9 (1.6)
Observational data: associations, not effects.
Further findings
Association of positron emission tomography (PET)/CT signal with 68 tender joint count
- Significant positive relationship, SUVmax
- P < 0.001
- Significant positive relationship, PET/CT-JI
- P < 0.001
Association of PET/CT signal with tender entheses count
- Significant positive relationship, SUVmax
- P < 0.001
- Significant positive relationship, PET/CT-JI
- P = 0.002
Association of PET/CT signal with US findings
- No correlation, SUVmax
- P = 0.969
- No correlation, PET/CT-JI
- P = 0.720
Risk of developing psoriatic arthritis (PsA) with relevant synovio-entheseal 68Ga-FAPI-04 uptake
- Statistically significant higher risk of PsA
- P = 0.02
- Independent of ultrasound findings
- Survival analyses in patients with at least 6 months of follow-up
Original publication
Anatomical pattern of entheseal and synovial fibroblast activation in patients with psoriasis and its risk of developing psoriatic arthritis. RMD Open. Published 11 June 2024. doi:10.
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