Spondyloarthritis & psoriatic arthritis
Increased synovial and entheseal fibroblast activation detected by 68 Ga-FAPI-PET/CT is associated with the development of psoriatic arthritis in psoriasis patients with arthralgia
Main finding · Progression to PsAResult — go to the resultHazard ratio 7.1 95% CI 0.9–53.6Authors' conclusion
In psoriasis patients with arthralgia, 68Ga-FAPI uptake, indicating fibroblast activation, is associated with higher BMI, more pain, subclinical US changes and concomitant OA. Pathological 68Ga-FAPI uptake at articular sites was indicative of higher risk of progression to PsA in our cohort
Study context
- Population
- Psoriasis patients with arthralgia undergoing 68Ga-FAPI-PET/CT
- Participants
- 45 patients
- Exposure
- FAPI positive vs FAPI negative
- FAPI positiven = 37
- FAPI negativen = 8reference
- Outcome
- Progression to psoriatic arthritis (PsA)
Methodological detailssurvival analyses
- Survival analyses
Main finding
As reported in the abstract
Hazard ratio
7.1
95% CI 0.9–53.6
log-rank p=0.028
Events by group
FAPI positivevs FAPI negative
HR 7.1 (95% CI 0.9–53.6); log-rank p=0.028
Observational data: associations, not effects.
Further findings
Clinical characteristics, FAPI positive vs negative
- Significantly higher body mass index (BMI) in FAPI positive
- P = 0.036
- Significantly higher DAS28-CRP in FAPI positive
- P = 0.033
Joint-level 68Ga-FAPI uptake by ultrasound (US) findings
- Low-grade synovial hyperplasia, OR
- 1.77 (95% CI 1.08 to 2.89)
- Entheseal Power Doppler, OR
- 3.80 (95% CI 1.66 to 8.72)
- Uptake more likely with concomitant osteoarthritis (OA); most frequent in large joints and mechanically stressed sites
Original publication
Increased synovial and entheseal fibroblast activation detected by 68 Ga-FAPI-PET/CT is associated with the development of psoriatic arthritis in psoriasis patients with arthralgia. RMD Open. Published 23 March 2026. doi:10.
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