Spondyloarthritis & psoriatic arthritis
68Ga-FAPI and 18F-NaF PET/CT in psoriatic arthritis: a comparative study
Authors' conclusion
The positivity rates of 68Ga-FAPI- and 18F-NaF PET/CT were different in patients with PsA in peripheral joints, entheses, and axial joints. The extent of joint involvement as shown in 68Ga-FAPI PET/CT correlated with clinical and US variables as well as with disease activity.
Study context
- Population
- Participants with PsA (female 7/16, age 42.31 ± 10.66 years)every participant had both tracers
- Participants
- 16 participants
- Comparison
- 68Ga-FAPI PET/CT vs 18F-NaF PET/CT
- Outcome
- Performance of 68Ga-FAPI PET/CT in PsA compared with 18F-NaF PET/CT: PET-positive lesions at peripheral joints, entheses and axial joints
Methodological detailsdual-tracer PET/CT
- Dual-tracer PET/CT
Performance
As reported in the abstract
PET positivity rate by site
Positivity rate, peripheral joints
Positivity rate, entheses
Positivity rate, axial joints
Further findings
| Outcome | PET-positive (68Ga-FAPI) | PET-negative (68Ga-FAPI) | P value |
|---|---|---|---|
| DAS28, PET-positive vs PET-negative with 68Ga-FAPI | 5.25 ± 1.84 | 2.55 ± 0.94 | P = 0.037 |
DAS28, PET-positive vs PET-negative with 68Ga-FAPI
- No DAS28 difference with 18F-NaF
Correlation of 68Ga-FAPI PET joint count with clinical, US and disease activity variables
- Tender joint count, r (P = 0.017)
- 0.604
- Swollen joint count, r (P = 0.001)
- 0.773
- DAS28-CRP, r (P = 0.032)
- 0.556
- Psoriatic Arthritis Disease Activity Score (PASDAS), r (P = 0.038)
- 0.540
- PsASon13, r (P = 0.005)
- 0.701
- No correlation observed with 18F-NaF PET/CT
Original publication
68Ga-FAPI and 18F-NaF PET/CT in psoriatic arthritis: a comparative study. Rheumatology (Oxford). Published 22 November 2024. doi:10.
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