Spondyloarthritis & psoriatic arthritis
Total-body positron emission tomography: a tool for systemic, quantitative evaluation of the inflammatory burden of psoriatic arthritis
Authors' conclusion
TB-PET/CT identified inflammatory pathologies characteristic to all clinical domains of PsA and thus provided an in vivo evaluation of systemic PsA inflammatory burden.
Study context
- Population
- Adults with psoriatic arthritis (PsA), rheumatoid arthritis (RA) or osteoarthritis (OA) undergoing 20-min total body-positron emission tomography (TB-PET)/computed tomography (CT) with [18F]FDG
- Participants
- 71 adults
- Exposure
- TB-PET/CT vs clinical domain-specific assessment in PsA; PsA vs RA and OA uptake patterns
- PsAn = 40
- RAn = 16
- OAn = 15
- Outcome
- [18F]FDG uptake by PsA domain and concordance with clinical assessment
Methodological detailstotal-body PET/CT with [18F]FDG, qualitative and quantitative assessment, comparison with clinical domain-specific assessment
- Total-body PET/CT with [18F]FDG
- Qualitative and quantitative assessment
- Comparison with clinical domain-specific assessment
Main finding
As reported in the abstract
- Uptake consistent with joint involvement and enthesitis in PsA
- 100%
- Nail matrix pathology in PsA
- 53%
- Spinal involvement in PsA
- 60%
- Active sacroiliitis in PsA
- 13%
- Dactylitis in PsA
- 10%
- Concordance TB-PET vs clinical assessment, joints
- 75%
- Concordance TB-PET vs clinical assessment, entheses
- 79%
- Concordance TB-PET vs clinical assessment, nails
- 65%
- TB-PET positive, clinically negative joints
- 15%
- TB-PET positive, clinically negative entheses
- 20%
- TB-PET positive, clinically negative nails
- 13%
Observational data: associations, not effects.
Original publication
Total-body positron emission tomography: a tool for systemic, quantitative evaluation of the inflammatory burden of psoriatic arthritis. Rheumatology (Oxford). Published 23 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →