Spondyloarthritis & psoriatic arthritis
Different disease activity trajectories in early axial spondyloarthritis lead to significantly different long-term outcomes: a trajectory-based analysis of the DESIR cohort over 10 years
Authors' conclusion
The k-means method revealed distinct disease activity trajectories in axSpA. Higher disease activity trajectories were associated with a higher prevalence of fibromyalgia and poorer outcomes, except for structural progression, which was comparable across trajectories.
Study context
- Population
- Patients with early (recent-onset) axial spondyloarthritis (axSpA) in the DESIR cohort with at least three Axial Spondylitis Disease Activity Score (ASDAS) values, followed for 10 years
- Participants
- 601 patients
- Exposure
- ASDAS disease activity trajectories over 10 years
- Outcome
- ASDAS disease activity trajectories and their impact on long-term outcomes (TNFi exposure, structural progression, function, quality of life, sick leave, CV events)
- Follow-up
- 10 years
Methodological detailsmulticentre, trajectory-based analysis, k-means clustering, multinomial multivariable regression
- Multicentre
- Trajectory-based analysis
- K-means clustering
- Multinomial multivariable regression
Main finding
As reported in the abstract
ASDAS trajectories
- Five ASDAS trajectories identified: tA, tD, tB, tC, tE
- tA more likely male, university degree, white-collar jobs, HLA B27 positive, less fibromyalgia
Observational data: associations, not effects.
Further findings
Long-term outcomes, tE vs lower ASDAS trajectory
- Bath Ankylosing Spondylitis Functional Index (BASFI), tE vs lower ASDAS trajectory
- 50/100 vs 7/100
- TNF inhibitors (TNFi) exposure, tE vs lower ASDAS trajectory
- 74% vs 29%
- Cardiovascular (CV) events, tE vs lower ASDAS trajectory
- 5.7% vs 0
Structural progression
- Low but comparable across trajectories, except higher sacroiliac joint progression in tB
Original publication
Different disease activity trajectories in early axial spondyloarthritis lead to significantly different long-term outcomes: a trajectory-based analysis of the DESIR cohort over 10 years. RMD Open. Published 22 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →