Spondyloarthritis & psoriatic arthritis
Construct validity and responsiveness of ASAS Health Index assessed in two longitudinal studies of tumour necrosis factor alpha inhibitor initiation and dose reduction in patients with axial spondyloarthritis
Authors' conclusion
ASAS HI showed good construct validity, discriminatory ability and responsiveness.
Study context
- Population
- Patients with axial spondyloarthritis (SpA) initiating or tapering tumour necrosis factor inhibitor (TNFi)
- Participants
- 45 vs 106
- Comparison
- MANGO vs DOBIS
- MANGOn = 45
- DOBISn = 106
- Outcome
- Construct validity, discriminatory ability and responsiveness of ASAS HI in relation to patient-reported outcome measures (PROMs), MRI and radiography
Methodological detailssecondary analysis of two longitudinal studies, multivariate regression
- Secondary analysis of two longitudinal studies
- Multivariate regression
Performance
As reported in the abstract
Responsiveness of ASAS HI
| Test or model | Standardised response mean (SRM) | Effect size (ES) |
|---|---|---|
| MANGO | −1.3 | −1.7 |
| DOBIS | 0.7 | 0.6 |
Standardised response mean (SRM)
MANGO−1.3
DOBIS0.7
Effect size (ES)
MANGO−1.7
DOBIS0.6
- Good discriminatory ability for almost all outcome variables by ASAS HI health status groups and change categories
- P ≤ 0.001
Further findings
- Clinical responders at week 16 (MANGO)
- 68% · 30
- Flare after tapering (DOBIS)
- 99% · 105 of 106
- Time to flare (DOBIS)
- 31 · mean · SD; min-max 17; 2.7-81 · weeks
Change in ASAS HI over time
- MANGO: ASAS HI significantly decreased from baseline to week 4, 16 and 52
- DOBIS: significantly increased from baseline to flare and significantly decreased from flare to week 96
Original publication
Construct validity and responsiveness of ASAS Health Index assessed in two longitudinal studies of tumour necrosis factor alpha inhibitor initiation and dose reduction in patients with axial spondyloarthritis. RMD Open. Published 20 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →