Spondyloarthritis & psoriatic arthritis
Role of inflammatory burden and treatment on joint space width in psoriatic arthritis—a high-resolution peripheral quantitative computed tomography study
Authors' conclusion
Higher inflammatory burden as reflected by longer disease duration, higher ESR levels, and damage joint count was negatively associated with mean, maximum, and minimum JSW, while suppression of inflammation using bDMARDs seems to limit the decline in JSW.
Study context
- Population
- Psoriatic arthritis (PsA) patients who underwent high-resolution peripheral quantitative computed tomography (HR-pQCT) of the second to fourth metacarpophalangeal joints (median age 57.0 years; median disease duration 21 years)37 (55.2%) males
- Participants
- 67 patients
- Outcome
- Association between disease-related variables and JSW (JSV, mean, minimum and maximum JSW, JSW asymmetry and distribution) on HR-pQCT
Methodological detailsHR-pQCT of MCPJ 2-4, multivariable linear regression
- HR-pQCT of MCPJ 2-4
- Multivariable linear regression
Main finding
As reported in the abstract
Associations with joint space metrics (multivariable linear regression)
- Males had larger joint space volume (JSV) (MCPJ 2-4), mean (MCPJ 4) and maximum joint space width (JSW) (MCPJ 3)
- Longer disease duration (MCPJ 2-3) and higher ESR (MCPJ 3) negatively associated with mean and maximum JSW
- Higher damage joint count negatively associated with mean and minimum JSW (MCPJ 2)
- csDMARD use negatively associated with minimum JSW (MCPJ 3)
- bDMARD use positively associated with minimum JSW (MCPJ 2)
Observational data: associations, not effects.
Original publication
Role of inflammatory burden and treatment on joint space width in psoriatic arthritis—a high-resolution peripheral quantitative computed tomography study. Arthritis Res Ther. Published 3 August 2023. doi:10.
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