Spondyloarthritis & psoriatic arthritis
Bone properties and biomechanics in patients with psoriatic disease: a cross-sectional study with high-resolution peripheral quantitative CT (HRpQCT)
Authors' conclusion
Psoriatic disease negatively impacted bone integrity. Patients with psoriatic disease seemed to have lower bone density and more microarchitectural alteration that impacted on biomechanics properties. Nail involvement was associated with decreased bone stiffness in psoriatic disease.
Study context
- Population
- Patients with PsO, psoriatic arthritis (PsA) and age-matched healthy controls (HCs), Department of Dermatology and Rheumatology, Verona centre; HRpQCT of radius and finger joints of the non-dominant handconsecutively enrolled
- Participants
- 51 / 39 / 24
- Exposure
- PsO vs PsA vs age-matched HCs
- PsOn = 51
- PsAn = 39
- HCn = 24reference
- Outcome
- Prevalence and determinants of bone microarchitectural damage
Methodological detailsage-matched healthy controls, HRpQCT, finite element analysis (uFEA)
- Age-matched healthy controls
- HRpQCT
- Finite element analysis (uFEA)
Main finding
As reported in the abstract
Bone density, microstructure and biomechanics (HRpQCT)
- Distal radius total and cortical volumetric BMD (Ct.BMD) lower in PsA and PsO vs HC
- Distal radius uFEA: significant reduction of stiffness in PsA vs both HC and PsO
- Distal interphalangeal (DIP) joints: Ct.BMD and trabecular volumetric BMD lower in PsA and PsO vs HC
- Nail involvement negatively associated with bone stiffness at proximal and distal region of the DIPs
Observational data: associations, not effects.
Original publication
Bone properties and biomechanics in patients with psoriatic disease: a cross-sectional study with high-resolution peripheral quantitative CT (HRpQCT). RMD Open. Published 4 March 2026. doi:10.
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