Spondyloarthritis & psoriatic arthritis
Depressive symptoms are associated with fatigue, poorer functional status and less engagement in sports in axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA): an analysis from the RABBIT-SpA cohort
An erratum to this article was published (Arthritis Res Ther, 11 Oct 2024 ↗)
Authors' conclusion
We confirmed a high prevalence of depressive symptoms in both PsA and axSpA. Factors negatively associated with the presence of depressive symptoms were fatigue, not engaging in sports, and greater functional limitations.
Study context
- Population
- Patients from the RABBIT-SpA cohort with axSpA or PsA and a valid WHO-5 Well-Being Index score at baseline
- Participants
- 2,470 patients
- Exposure
- Moderate or severe vs no or mild depressive symptoms
- axSpAn = 1,245
- PsAn = 1,225
- Outcome
- Prevalence of depressive symptoms (moderate or severe) and associated sociodemographic and clinical factors
- Follow-up
- Baseline
Methodological detailsRABBIT-SpA, real-world cohort, baseline analysis, logistic regression
- RABBIT-SpA
- Real-world cohort
- Baseline analysis
- Logistic regression
Main finding
As reported in the abstract
Moderate depressive symptoms
8%
Severe depressive symptoms
21%
Observational data: associations, not effects.
Further findings
Characteristics of patients with moderate or severe vs no or mild depressive symptoms · baseline
- Less likely to engage in sports, more comorbidities, higher disease activity, functional limitation, fatigue and pain scores, more analgesics
Factors associated with depressive symptoms in axSpA · baseline
- Higher disease activity, greater functional impairment and more severe fatigue: more likely; more years in education and sports ≥1 h/week: less likely
Factors associated with depressive symptoms in PsA · baseline
- Greater functional impairment and more severe fatigue: more likely; sports ≥1 h/week: less likely
Original publication
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