Spondyloarthritis & psoriatic arthritis
Predictive Value of Severe Symptoms for Residual Disease After Transitioning From High to Low Disease Activity in Axial Spondyloarthritis: A Longitudinal Study
Main finding · Residual disease after achieving ID/LDAResult — go to the resultOdds ratio 5.09 95% CI 1.76–14.71Authors' conclusion
Severe symptoms when in HDA state predict patient-experienced, but not objective, residual disease in axSpA, whereas VHDA status does not predict either form.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) transitioning from HDA (Axial Spondyloarthritis Disease Activity Score (ASDAS) ≥ 2.1) to ID/LDA (ASDAS < 2.1), SpA-Net registry58 [43.6%] female
- Participants
- 133 patients
- Exposure
- Severe symptoms or very high disease activity (VHDA) status when in HDA state vs not, as predictors of residual disease after achieving ID/LDA
- Severe symptomsn = 107
- VHDAn = 16
- Outcome
- Residual disease (≥ 1 patient-experienced or objective disease indicator) after achieving ID/LDA
- Follow-up
- ID/LDA timepoint
Methodological detailsregistry-based (SpA-Net), longitudinal, logistic regression
- Registry-based (SpA-Net)
- Longitudinal
- Logistic regression
Main finding
Residual disease after achieving ID/LDA
Odds ratio
5.09
95% CI 1.76–14.71
Severe symptoms
OR 5.09 (95% CI 1.76–14.71)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Prevalence of residual disease at ID/LDA timepoint
- Patient-experienced residual disease
- 70.7% (n = 94/133)
- Objective residual disease
- 54% (n = 37/68)
Original publication
Predictive Value of Severe Symptoms for Residual Disease After Transitioning From High to Low Disease Activity in Axial Spondyloarthritis: A Longitudinal Study. J Rheumatol. Published 1 October 2025. doi:10.
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