Spondyloarthritis & psoriatic arthritis
The association between residual disease and the risk of future disease flares in axial spondyloarthritis: A longitudinal study
An erratum to this article was published (Semin Arthritis Rheum, Jun 2026 ↗)
Authors' conclusion
The majority of axSpA patients in an ID/LDA state have patient-experienced or objective residual disease. Patient-experienced, but not objective, residual disease predicts flares in patients with lower education levels, suggesting prognostic relevance of residual symptoms in axSpA.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) in ID/LDA (ASDAS <2.1) from SpA-Net (mean age 50.1 ± 13.2 years, 53 [39.3%] females)
- Participants
- 80 vs 60
- Exposure
- Residual disease vs no residual disease while in ID/LDA
- Patient-experienced residual diseasen = 80
- Objective residual diseasen = 60
- Outcome
- Flare (ASDAS increase ≥0.9 and shift from ID/LDA to ASDAS ≥2.1) and time to flare
- Follow-up
- Within 12 months
Methodological detailslongitudinal, web-based monitoring system (SpA-Net), multivariable logistic and Cox regression
- Longitudinal
- Web-based monitoring system (SpA-Net)
- Multivariable logistic and Cox regression
Main finding
As reported in the abstract
Flare and time-to-flare (adjusted)
Patient-experienced residual diseaseEstimate (95% CI)
Flare risk in those with lower education levels
OR 17.7(2.1–147.5)
Time-to-flare in those with lower education levels
HR 12.1(1.6–91.9)
Observational data: associations, not effects.
Further findings
Flare occurrence (all patients)
- Patients with a flare
- 34 (25.2%)
- Mean time to flare
- 190 (SD 97) days
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The association between residual disease and the risk of future disease flares in axial spondyloarthritis: A longitudinal study. Semin Arthritis Rheum. Published 8 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →