Spondyloarthritis & psoriatic arthritis
Performance of clinical, laboratory and imaging features for diagnosing spondyloarthritis—a systematic literature review and meta-analysis
An erratum to this article was published (Rheumatology (Oxford), 1 Nov 2024 ↗)
Authors' conclusion
Imaging features and CRP have good diagnostic value for axSpA. However, the specificity of other features, especially HLA-B27 and IBP, is lower than previously known.
Study context
- Population
- Patients with suspected SpA46 studies included
- Comparison
- Clinical, laboratory and imaging SpA features vs rheumatologist's diagnosis of SpA (reference)
- Outcome
- Pooled sensitivity, specificity, LR+ and LR- of SpA features for diagnosing each SpA subtype
Methodological detailsmeta-regression, separate meta-analysis per SpA subtype, 13 844 articles screened
- Meta-regression
- Separate meta-analysis per SpA subtype
- 13 844 articles screened
Pooled result
As reported in the abstract
Diagnostic performance for axial SpA (axSpA)
| Group | LR+ | LR- |
|---|---|---|
| Sacroiliitis on MRI, pelvic radiograph damage, elevated CRP | 3.9-17.0 | 0.5-0.7 |
| HLA-B27 | 3.1 | |
| Inflammatory back pain (IBP) | ≈1 | 0.3 |
| Peripheral features and extramusculoskeletal manifestations | 1.6-5.0 | ≈1 |
LR+
Sacroiliitis on MRI, pelvic radiograph damage, elevated CRP3.9-17.0
HLA-B273.1
Inflammatory back pain (IBP)≈1
Peripheral features and extramusculoskeletal manifestations1.6-5.0
LR-
Sacroiliitis on MRI, pelvic radiograph damage, elevated CRP0.5-0.7
HLA-B27— not stated in the abstract
Inflammatory back pain (IBP)0.3
Peripheral features and extramusculoskeletal manifestations≈1
Original publication
Performance of clinical, laboratory and imaging features for diagnosing spondyloarthritis—a systematic literature review and meta-analysis. Rheumatology (Oxford). Published 1 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →