Spondyloarthritis & psoriatic arthritis
Disease activity and mental health symptoms in axial spondyloarthritis: concordant or discordant?
Authors' conclusion
We did not identify the hypothesized subgroups with discordant disease activity and mental health symptoms. Instead, these domains were closely aligned at baseline and following treatment, suggesting that these symptoms influence each other.
Study context
- Population
- Axial spondylarthritis (axSpA) patients from the ASAS Health Index International Validation Study206 in trajectory subset
- Participants
- 1,292 patients
- Primary endpoint
- Subgroups with discordant HADS subscores and ASDAS at baseline and after treatment change
- Follow-up
- 6 months
Methodological detailslatent class analysis, trajectory modelling
- Latent class analysis
- Trajectory modelling
Primary result
As reported in the abstract
Latent classes and trajectories of HADS and ASDAS
- Baseline: three groups with concordant Hospital Anxiety and Depression Scale (HADS) subscores and ASDAS; high HADS/ASDAS group had more peripheral joint involvement and higher CRP
- 3
- Trajectory: four groups with concordant HADS and ASDAS changes; comparatively low baseline values
- 54%
- Trajectory: medium baseline
- 33%
- Trajectory: high baseline with marked improvement (HADS-depression Δ11, HADS-anxiety Δ9, ASDAS Δ2.8)
- 7%
- Trajectory: high baseline with limited ASDAS improvement (Δ1.4) and minimal change in anxiety (Δ0.6)
- 6%
Original publication
Disease activity and mental health symptoms in axial spondyloarthritis: concordant or discordant? Rheumatology (Oxford). Published 29 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →