Spondyloarthritis & psoriatic arthritis
Targeting the MICA-mediated oxidative stress-immune axis: a novel therapeutic strategy for ankylosing spondylitis
Authors' conclusion
This integrative multiomics analysis revealed OS-related genes as causal drivers of AS through immune dysregulation pathways.
Study context
- Population
- Genetic, mRNA microarray and single-cell RNA-seq (scRNA-seq) data on oxidative stress (OS)-related genes, 731 immune phenotypes and ankylosing spondylitis (AS) risk
- Outcome
- AS risk
Methodological detailsintegrative multiomics analysis, two-sample Mendelian randomisation, mediation analysis, western blotting and scRNA-seq validation
- Integrative multiomics analysis
- Two-sample Mendelian randomisation
- Mediation analysis
- Western blotting and scRNA-seq validation
Main finding
As reported in the abstract
MICA protein abundance, positive association with AS risk (OR)
OR=1.89; PFDR=3.6×10-4
Mediated proportion through T cell subsets, particularly CD28+ resting Tregs
82.3%
Clinical validation: lymphocyte-associated protection (OR, 95% CI)
OR: 0.64, 95%CI: 0.54-0.76
Original publication
Targeting the MICA-mediated oxidative stress-immune axis: a novel therapeutic strategy for ankylosing spondylitis. Clin Exp Rheumatol. Published 28 September 2025. doi:10.
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