Spondyloarthritis & psoriatic arthritis
Neutrophil Extracellular Traps–Associated RNA Impedes CD4+ Treg Differentiation by TLR7–IRF7 Axis in Ankylosing Spondylitis
Authors' conclusion
Elevated NETs impeded CD4+ Treg differentiation by activating the TLR7-IRF-7 axis via their associated RNA in AS
Study context
- Population
- Patients with ankylosing spondylitis (AS) and AS model SKG mice
Methodological detailspatients with AS and SKG mouse model, RNA sequencing
- Patients with AS and SKG mouse model
- RNA sequencing
Main finding
As reported in the abstract
- Neutrophil extracellular traps (NETs) levels elevated locally and systemically in patients with AS and SKG mice, impeding CD4+ Treg differentiation
- Blocking NETs formation via sivelestat (SVT) or CI-amidine restored the CD4+ Treg ratio and alleviated inflammation in SKG mice
- NETs internalized by CD4+ T cells; their associated RNA activated the TLR7–IRF-7 axis, inhibiting Treg differentiation
- Inhibiting CD4+ T-cell endocytosis, removing bound RNA or blocking the TLR7–IRF-7 axis abrogated the negative effect of NETs on Treg differentiation
Original publication
Neutrophil Extracellular Traps–Associated RNA Impedes CD4+ Treg Differentiation by TLR7–IRF7 Axis in Ankylosing Spondylitis. Arthritis Rheumatol. Published 5 May 2025. doi:10.
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