Spondyloarthritis & psoriatic arthritis
The inhibition of miR-125b-5P prevented Treg differentiation through activating STAT3/HIF-1α pathway in peripheral blood mononuclear cells (PBMCs) of ankylosing spondylitis
Authors' conclusion
MiR-125b-5p regulates Treg cell differentiation and function by regulating STAT3 expression in AS patients. Moreover, NOX2 also affects Treg differentiation through the STAT3/HIF-1α pathway.
Study context
- Population
- PBMCs from ankylosing spondylitis (AS) patients and healthy controls (HC)
- Comparison
- PBMCs from AS patients vs HC
- Outcome
- Role of miR-125b-5p in regulating Treg cell differentiation and function in AS
Main finding
As reported in the abstract
- Treg proportion significantly decreased in AS PBMCs, with decreased FOXP3, IL-2 and IL-10 expression
- STAT3 upregulated in AS PBMCs; STAT3 overexpression suppressed FOXP3, STAT3 knockdown restored it
- miR-125b-5p directly interacts with STAT3 mRNA 3'-UTR, repressing its expression (dual-luciferase assay)
- miR-125b-5p significantly downregulated in AS PBMCs
- miR-125b-5p overexpression increased Treg frequency and IL-10 and TGF-β1 secretion by inhibiting STAT3/HIF-1α axis
- STAT3 interacts with NOX2; NOX2 overexpression modulated STAT3/HIF-1α pathway, affecting Treg differentiation
Original publication
The inhibition of miR-125b-5P prevented Treg differentiation through activating STAT3/HIF-1α pathway in PBMCs of ankylosing spondylitis. Arthritis Res Ther. Published 12 February 2026. doi:10.
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