Spondyloarthritis & psoriatic arthritis

The likelihood of joint inflammation recurrence in previously affected joints during psoriatic arthritis disease course

Ann Rheum DisPublished Retrospective cohort study

Main finding · Future joint swellingResult — go to the resultOdds ratio 2.88 95% CI 2.61–3.18

Authors' conclusion

This study identified a strong association between baseline joint swelling and subsequent swelling episodes in patients with PsA.

Study context

Population
Patients with PsA followed at the Tel Aviv Medical Center Rheumatology Institute; 44% male, mean age 48 y/o (SD 15), mean disease duration 1 yearjoints assessed in 492 patients
Participants
33,456 patients
Exposure
Joints swollen at baseline vs joints not swollen at baseline
  • Swollen at baselinen = 1,402
Outcome
Recurrence of joint inflammation (swelling, SJC68) in previously affected joints during follow-up
Methodological detailsreal-world data, single-centre, mixed-effects logistic regression adjusted for joint location and follow-up visit, Median 6 (IQR 4-9) follow-up visits
  • Real-world data
  • Single-centre
  • Mixed-effects logistic regression adjusted for joint location and follow-up visit
  • Median 6 (IQR 4-9) follow-up visits

Main finding

Future joint swelling · during follow-up

Odds ratio

2.88

95% CI 2.61–3.18

Events by group

Swollen at baseline

36.7%

514 of 1402

Swollen at baselinevs Not swollen at baseline
OR 2.88 (95% CI 2.61–3.18)

As reported in the abstract

Observational data: associations, not effects.

Further findings

Patients with at least 1 swollen joint at baseline

Patients with ≥1 swollen joint
420 (85%)
Median SJC68
2 (1-5)

Original publication

The likelihood of joint inflammation recurrence in previously affected joints during psoriatic arthritis disease course. Ann Rheum Dis. Published 26 September 2025. doi:10.1016/j.ard.2025.08.020

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