Spondyloarthritis & psoriatic arthritis
Development and validation of a Disease Activity index for PSoriatic Arthritis based on 44 joints (DAPSA44)
Authors' conclusion
These findings support the use of DAPSA44 as a comparable tool to the original DAPSA for assessing disease activity due to peripheral arthritis in SpA, especially in situations where only a reduced joint count is available.
Study context
- Population
- Patients with spondyloarthritis (SpA) (axSpA, pSpA and PsA) in the ASAS-PerSpA studyvalidation cohort n = 2757
- Participants
- 4,121 patients
- Comparison
- DAPSA44 vs original DAPSA
- Outcome
- Construct validity of DAPSA44: agreement with original DAPSA (ICC, weighted kappa), correlations with external constructs, discrimination between known groups (SMD)
Methodological detailsderivation and validation cohorts (1:2 random allocation, stratified for diagnosis and country), mixed-effects linear regression
- Derivation and validation cohorts (1:2 random allocation, stratified for diagnosis and country)
- Mixed-effects linear regression
Performance
As reported in the abstract
Agreement between original-DAPSA and DAPSA44 (validation cohort)
ICC
0.98
Kappa (disease activity states)
0.95
Discriminatory ability, active/inactive disease, all scenarios: SMD
> 0.8
Further findings
Conversion factors SJC66/TJC68 to SJC44/TJC44 (derivation cohort, n = 1364)
- TJC
- 1.30
- SJC
- 1.34
Original publication
Development and validation of a Disease Activity index for PSoriatic Arthritis based on 44 joints (DAPSA44). Ann Rheum Dis. Published 25 September 2025. doi:10.
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