Spondyloarthritis & psoriatic arthritis
Evaluation of instruments assessing peripheral arthritis in spondyloarthritis: an analysis of the ASAS-PerSpA study
Authors' conclusion
In our construct validity analysis, all disease activity instruments assessing peripheral arthritis had a good performance as reflected in the correlations with external constructs and the known-group discrimination. The highest discriminatory capacity to distinguish between 'active/inactive disease' was observed for composite scores, including joint counts, like DAS28 and DAPSA.
Study context
- Population
- Patients with a diagnosis of axSpA, pSpA or psoriatic arthritis (PsA) in the ASAS-PerSpA studymean age 45 [SD, 14] years, 61% males
- Participants
- 4,121 patients
- Exposure
- Disease activity instruments assessing peripheral arthritis in spondyloarthritis (SpA)
- Outcome
- Construct validity, including known-group discrimination (active/inactive disease by PGA [≥5/<5] and SJC [≥1/0 and ≥2/<2]), analysed with SMDs
Methodological detailsanalysis of the ASAS-PerSpA study, construct validity analysis
- Analysis of the ASAS-PerSpA study
- Construct validity analysis
Main finding
As reported in the abstract
- Correlations with external constructs (BASFI, ASAS Health Index, EQ-5D): all instruments performed excellently (100% hypotheses confirmed)
- Known-group discrimination: all disease activity measures except C-reactive protein (CRP) presented standardised mean differences (SMDs) ≥ 0.8 (good discrimination)
- Higher SMDs for DAS28 followed by DAPSA
- Across all Patient Global Assessment (PGA) and Swollen Joint Count (SJC) combinations, better performance for composite scores including joint counts
Observational data: associations, not effects.
Further findings
Known-group discrimination by disease phenotype
- Results similar across disease phenotypes
Original publication
Evaluation of instruments assessing peripheral arthritis in spondyloarthritis: an analysis of the ASAS-PerSpA study. Ann Rheum Dis. Published 17 March 2025. doi:10.
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