Spondyloarthritis & psoriatic arthritis
Diversity in Axial Spondyloarthritis Drug Trials: Enrollment by Sex, Race, Ethnicity, and Geographic Region
Authors' conclusion
The proportion of women enrolled in axSpA drug trials largely reflects disease demographics. Race and ethnicity reporting has improved over time. Whereas participation of Asian, American Indian/Alaska Native and Hispanic/Latino patients has increased, Black and Native Hawaiian/Pacific Islander representation has remained low.
Study context
- Population
- Completed phase II–IV drug trials in adults with axial spondyloarthritis (axSpA), 2000–2023, with results posted on ClinicalTrials.gov
- Participants
- 16,162 participants59 trials
- Outcome
- Demographic (sex, race, ethnicity) and geographic diversity of enrollment in axSpA drug trials
Methodological detailsClinicalTrials.gov data, completed phase II-IV drug trials, 2000–2023, with results posted
- ClinicalTrials.gov data
- Completed phase II-IV drug trials, 2000–2023, with results posted
Main finding
As reported in the abstract
Enrollment by sex, race, ethnicity and region
- Female participants, overall
- 30%
- Female participants, r-axSpA trials
- 25%
- Female participants, axSpA trials
- 34%
- Female participants, nr-axSpA trials
- 48%
- Trials reporting race
- 31 (53%)
- Trials reporting both race and ethnicity
- 12 (20%)
- Trials reporting race, 2000-2010 / 2011-2015 / 2016-2020
- 9% / 53% / 100%
- White (of 10,037 with race data)
- 82%
- Asian
- 15%
- American Indian/Alaska Native
- 2%
- Black
- 1%
- Native Hawaiian/Pacific Islander
- 0.02%
- Asian representation, 2011-2015 to 2016-2020
- 4% to 19%
- American Indian/Alaska Native representation, 2011-2015 to 2016-2020
- 1% to 3%
- Black representation, consistently low
- 1%
- Hispanic/Latino (of 3577 with ethnicity data)
- 14%
- Hispanic/Latino, 2011-2015 to 2016-2020
- 1% to 14%
- Countries enrolling participants (51 trials with location data)
- 53
- Sub-Saharan Africa share of enrollment sites (lowest)
- 0%
- South/Central Asia share of enrollment sites
- 2%
Original publication
Diversity in Axial Spondyloarthritis Drug Trials: Enrollment by Sex, Race, Ethnicity, and Geographic Region. J Rheumatol. Published 15 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →