Spondyloarthritis & psoriatic arthritis
Rheumatoid arthritis and psoriatic arthritis: is the disease impact different? A large matching study at diagnosis and after 1 year of treatment
Main finding · SF-36 mental health, at diagnosis (PsA worse)Result — go to the resultDifference 5.04 units 95% CI 2.21–7.87Authors' conclusion
The disease impact of early RA patients is similar to matched early PsA patients on most PRO domains, except for mental health and functional limitations, which were worse in PsA after 1 year of treatment.
Study context
- Population
- Early rheumatoid arthritis (RA) and early psoriatic arthritis (PsA) patients from Rotterdam (tREACH), Dutch southwest (DEPAR) and Leiden (Early Arthritis Clinic (EAC)) cohorts
- Participants
- 391 / 416 / 702 / 99
- Exposure
- PsA vs RA patients, matched, at diagnosis and after 1 year of treatment
- RA-tREACHn = 391reference
- PsA-DEPARn = 416
- RA-EACn = 702reference
- PsA-EACn = 99
- Outcome
- Difference in disease impact (PROs): pain (Visual Analogue Scale (VAS) 0-100), fatigue (VAS), activity limitation (HAQ-DI), health impact (general health VAS, SF-36)
- Follow-up
- At diagnosis and after 1 year
Methodological detailspropensity-score matched, inverse probability weighted linear regression, multi-cohort (tREACH, DEPAR, EAC)
- Propensity-score matched
- Inverse probability weighted linear regression
- Multi-cohort (tREACH, DEPAR, EAC)
Main finding
SF-36 mental health, at diagnosis (PsA worse)
Difference
5.04 units
95% CI 2.21–7.87
PsA-DEPARvs RA-tREACH
difference 5.04 units (95% CI 2.21–7.87)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Difference (95% CI) | |
|---|---|---|
| SF-36 mental health after 1 year of treatmentBetween PsA-DEPAR and RA-tREACH · difference still existed | 3.88 (1.90–5.86) | |
| Activity limitations (HAQ-DI) after 1 year of treatmentPsA-EACvs RA-EACPsA-EAC had more activity limitations | −0.30 (−0.50 to −0.10) | |
| −50510Difference (linear scale) |
Original publication
Rheumatoid arthritis and psoriatic arthritis: is the disease impact different? A large matching study at diagnosis and after 1 year of treatment. RMD Open. Published 12 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →