Spondyloarthritis & psoriatic arthritis
The Effect of Early Attainment of Minimal Disease Activity on Radiographic Outcomes: A Real-World Longitudinal Cohort Study in Psoriatic Arthritis
Main finding · Radiographic changes during follow-upResult — go to the resultβ 0.05 95% CI 0.02–0.08Authors' conclusion
Radiographic changes during the 3-year follow-up were markedly higher in those unable to achieve MDA within the first year of follow-up
Study context
- Population
- Newly diagnosed psoriatic arthritis (PsA) with oligoarthritis or polyarthritis, Dutch southwest Early PsA cohort
- Participants
- 284 participants
- Exposure
- No minimal disease activity (MDA) vs sustained MDA in the first year after PsA diagnosis
- Sustained MDAn = 96reference
- Nonsustained MDAn = 83
- No MDAn = 105
- Outcome
- Radiographic changes (modified Total Sharp/van der Heijde score for PsA)
- Follow-up
- 3-year follow-up
Methodological detailsreal-world, longitudinal, linear mixed model
- Real-world
- Longitudinal
- Linear mixed model
Main finding
Radiographic changes during follow-up
β
0.05
95% CI 0.02–0.08
P < 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
- Baseline characteristics of No MDA
- 70%
Original publication
The Effect of Early Attainment of Minimal Disease Activity on Radiographic Outcomes: A Real-World Longitudinal Cohort Study in Psoriatic Arthritis. J Rheumatol. Published 15 May 2025. doi:10.
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