Spondyloarthritis & psoriatic arthritis
Analysis of Gut-Homing Receptors in Circulating Mucosal-Associated Invariant T Cells and Their Presence in Synovial Tissue From Patients With Axial Spondyloarthritis
Authors' conclusion
MAIT cells were activated and expressed Gut-Homing receptors, indicating their potential involvement in the gut-joint axis in axSpA. MAIT cell frequency and function were reduced by TNF blockade. MAIT cells could be found in synovial tissue in patients with axSpA.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) and healthy controls; synovial biopsies from patients with axSpA, RA and OA
- Participants
- 26 vs 27
- Comparison
- axSpA vs healthy controls (HCs)
- axSpAn = 26
- HCsn = 27reference
- Outcome
- Circulating MAIT cell phenotype
Methodological detailsflow cytometry, confocal microscopy
- Flow cytometry
- Confocal microscopy
Main finding
As reported in the abstract
- Higher frequency of CD3+ and CD8+ Mucosal-Associated invariant T (MAIT) cells expressing CD69, CCR9 and CD49d in axSpA, especially in the radiographic subgroup
- MAIT cells detected in a synovial biopsy sample from 1 patient with axSpA (of 3)
- After tumor necrosis factor (TNF) blockade, decrease in frequency of MAIT cells and TNF/IL-17A-producing MAIT cells
Original publication
Analysis of Gut-Homing Receptors in Circulating Mucosal-Associated Invariant T Cells and Their Presence in Synovial Tissue From Patients With Axial Spondyloarthritis. J Rheumatol. Published 15 May 2025. doi:10.
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