Spondyloarthritis & psoriatic arthritis
Gut Inflammation in Axial Spondyloarthritis Patients is Characterized by a Marked Type 17 Skewed Mucosal Innate‐like T Cell Signature
Authors' conclusion
Intestinal innate-like T cells display marked type 17 skewing in the inflamed gut mucosa of patients with nonradiographic axial SpA. γδ-hi T cells are linked to intestinal inflammation and disease activity in SpA.
Study context
- Population
- Treatment-naive patients with nr-axSpA and healthy controls undergoing ileocolonoscopy
- Participants
- 11 / 14 / 15
- Comparison
- nr-axSpA with vs without microscopic gut inflammation vs healthy controls
- Nonradiographic axial spondyloarthritis (SpA) with microscopic gut inflammationn = 11
- Nonradiographic axial SpA without microscopic gut inflammationn = 14
- Healthy controlsn = 15reference
- Outcome
- Mucosal innate-like T cells in gut inflammation
Methodological detailscross-sectional, intracellular flow cytometry, unsupervised clustering (FlowSOM)
- Cross-sectional
- Intracellular flow cytometry
- Unsupervised clustering (FlowSOM)
Main finding
As reported in the abstract
- Microscopic gut inflammation in nr-axSpA characterized by increased ileal intraepithelial γδ-hi T cells (γδ-T cell subset with elevated γδ-T cell receptor expression)
- γδ-hi T cells increased in peripheral blood mononuclear cells (PBMCs) of nr-axSpA vs healthy controls; strongly associated with ASDAS
- Abundance of mucosal-associated invariant T cells and invariant natural killer T cells unaltered
- Innate-like T cells in inflamed gut: increased RORγt, IL-17A and IL-22 with loss of T-bet; less pronounced in conventional T cells
- Gut inflammation associated with higher serum IL-17A
Further findings
Patients treated with TNF blockade
- Proportion of γδ-hi cells and RORγt expression in blood completely restored
Original publication
Gut Inflammation in Axial Spondyloarthritis Patients is Characterized by a Marked Type 17 Skewed Mucosal Innate‐like T Cell Signature. Arthritis Rheumatol. Published 4 October 2023. doi:10.
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