Spondyloarthritis & psoriatic arthritis
Endothelial mesenchymal transition promotes pannus formation in ankylosing spondylitis by activation of TGF-β/SMAD signalling pathway
Authors' conclusion
Our findings show that EndMT is involved in the promotion of pannus formation by TGF-β/SMAD signalling pathway activation in AS.
Study context
- Population
- Patients with ankylosing spondylitis (AS) and healthy subjects; Sacroiliac joint (SIJ) samples from AS patients and non-SpA autopsy controls
- Comparison
- AS vs healthy controls and non-SpA autopsy controls
- ASn = 48
- Healthy controlsn = 15reference
- ASn = three
- Non-SpA controln = threereference
- Outcome
- Serum TGF-β1 level
Methodological detailscase-control, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA)
- Case-control
- Immunohistochemistry
- ELISA
Main finding
As reported in the abstract
P < 0.01
- Increased expressions of TGF-β1, CTGF, α-SMA, vimentin and FSP-1 in AS SIJ vs non-SpA
- all p<0.05
- Decreased expressions of VE-cadherin and SMAD7 in AS SIJ vs non-SpA
- P < 0.01
Original publication
Endothelial mesenchymal transition promotes pannus formation in ankylosing spondylitis by activation of TGF-β/SMAD signalling pathway. Clin Exp Rheumatol. Published 26 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →