Spondyloarthritis & psoriatic arthritis
HLA-B27 status and inflammatory MRI lesions of the sacroiliac joints: a post hoc analysis in patients without axial spondyloarthritis
Authors' conclusion
HLA-B27 status has no significant influence on the occurrence and extent of SIJ lesions in patients with low back pain of non-inflammatory origin in either men or women.
Study context
- Population
- Non-axSpA patients with chronic low back pain of non-inflammatory origin90 women
- Participants
- 139 patients
- Comparison
- HLA-B27 positive vs HLA-B27 negative
- Primary endpoint
- Sex-specific influence of HLA-B27 status on inflammatory and structural SIJ MRI findings (sclerosis, erosion, fat metaplasia, BMO, ankylosis)
Methodological detailstwo readers, χ2 tests and t-tests, regression models
- Two readers
- χ2 tests and t-tests
- Regression models
Primary result
As reported in the abstract
- Erosion mean sum score (MSS), no significant difference by HLA-B27 positivity
- 0.91 vs 0.48; p=0.144
- Sclerosis MSS, no significant difference by HLA-B27 positivity
- 1.65 vs 1.88; p=0.576
- Fat metaplasia MSS, no significant difference by HLA-B27 positivity
- 0.56 vs 0.27; p=0.425
- Bone marrow oedema (BMO) MSS, no significant difference by HLA-B27 positivity
- 0.75 vs 0.59; p=0.460
- Ankylosis MSS, no significant difference by HLA-B27 positivity
- 0.06 vs 0.04; p=0.659
Original publication
HLA-B27 status and inflammatory MRI lesions of the sacroiliac joints: a post hoc analysis in patients without axial spondyloarthritis. RMD Open. Published 22 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →