Spondyloarthritis & psoriatic arthritis
Features of Axial Spondyloarthritis in Two Multicenter Cohorts of Patients with Psoriasis, Uveitis, and Colitis Presenting with Undiagnosed Back Pain
An erratum to this article was published (Arthritis Rheumatol, Apr 2026 ↗)
Authors' conclusion
Conducting MRI in all patients enhances diagnostic accuracy.
Study context
- Population
- Consecutive patients with undiagnosed chronic back pain attending dermatology, ophthalmology and gastroenterology clinics with psoriasis (PsO), acute anterior uveitis (AAU) or inflammatory bowel disease (IBD), referred to a local rheumatologistSASPIC-1 n = 212
- Comparison
- Frequency of axial spondyloarthritis (axSpA) by extra-articular presentation (PsO, AAU, IBD) and HLA-B27 status; Magnetic resonance imaging (MRI) in all patients (SASPIC-2) vs on demand (SASPIC-1)
- Outcome
- Proportion of patients diagnosed with axSpA by the final global evaluation
Methodological detailsScreening for Axial Spondyloarthritis in Psoriasis, Iritis, and Colitis (SASPIC), consecutive patients, structured diagnostic evaluation by rheumatologist with axSpA expertise, MRI on demand (SASPIC-1) vs MRI in all patients (SASPIC-2)
- SASPIC
- Consecutive patients
- Structured diagnostic evaluation by rheumatologist with axSpA expertise
- MRI on demand (SASPIC-1) vs MRI in all patients (SASPIC-2)
Performance
As reported in the abstract
Frequency of axSpA
Further findings
| Outcome | Values |
|---|---|
| axSpA diagnosis in HLA-B27 positive (subgroup) | SASPIC-1 PsO 70% · SASPIC-1 AAU 74.5% · SASPIC-1 IBD 66.7% · SASPIC-2 PsO 71.4% · SASPIC-2 AAU 87.8% · SASPIC-2 IBD 55.6% |
Musculoskeletal clinical features
- All musculoskeletal clinical features were nondiscriminatory
Impact of MRI
- MRI indicative of axSpA
- 60% to 80%
- MRI in all patients (SASPIC-2) vs on demand (SASPIC-1): fewer axSpA diagnoses in HLA-B27 negative with PsO or IBD
- 25%
Performance of ASAS classification criteria
- Greater with routine MRI (SASPIC-2), though sensitivity lower than previously reported
Original publication
Features of Axial Spondyloarthritis in Two Multicenter Cohorts of Patients with Psoriasis, Uveitis, and Colitis Presenting with Undiagnosed Back Pain. Arthritis Rheumatol. Published 3 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →