Spondyloarthritis & psoriatic arthritis
Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries
Authors' conclusion
In this SpA population, MMs were the most prevalent initial symptoms, with differences across diagnoses and depending on the presence of the HLA-B27 antigen.
Study context
- Population
- Patients fulfilling ESSG criteria for spondyloarthritis (SpA) from the REGISPONSER and RESPONDIA united registries (ankylosing spondylitis (AS) 68.3%, psoriatic arthritis (PsA) 19.9%, undifferentiated SpA 11.8%)2,208 REGISPONSER, 1859 RESPONDIA
- Participants
- 4,067 patients
- Exposure
- Initial musculoskeletal manifestations (MMs) vs EMMs; HLA-B27-positive vs HLA-B27-negative
- MMsn = 3,624
- EMMsn = 443reference
- Outcome
- First sign(s) or symptom(s) of SpA and their association with HLA-B27 status
Methodological detailsobservational, multicentre
- Observational
- Multicentre
Main finding
As reported in the abstract
Initial symptoms
- Low back pain as initial symptom
- 61.7%
- Lower-limb arthritis as initial symptom
- 38.5%
Observational data: associations, not effects.
Further findings
Diagnostic delay
Diagnostic delay
- Diagnostic delay longer with initial MMs than with EMMs
Original publication
Identification of the first signs or symptoms in different spondyloarthritis subtypes and their association with HLA-B27: data from REGISPONSER and RESPONDIA registries. RMD Open. Published 21 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →