Spondyloarthritis & psoriatic arthritis
Determinants of health-related quality of life and global functioning and health in axial SpA (axSpA), peripheral SpA (pSpA) and PsA: results from the ASAS-PerSpA study
Authors' conclusion
Disease activity and physical function are major HRQoL and GH determinants across SpA types, and clinical characteristics and sociodemographic factors play an important role
Study context
- Population
- Patients with axSpA, pSpA and PsA in the ASAS-perSpA study
- Participants
- 4,185 patients
- Exposure
- axSpA vs pSpA vs PsA
- axSpAn = 2,719
- pSpAn = 433
- PsAn = 1,033
- Outcome
- Determinants of HRQoL (EQ-5D) and global functioning and health (ASAS-HI)
Methodological detailsanalysis of the ASAS-perSpA study data, separate models per disease group
- Analysis of the ASAS-perSpA study data
- Separate models per disease group
Main finding
As reported in the abstract
- axSpA, health-related quality of life (HRQoL): disease activity (worse)
- β = −0.061
- axSpA, HRQoL: physical function (worse)
- β = −0.041
- axSpA, HRQoL: female sex (worse)
- β = −0.019
- axSpA, HRQoL: Fibromyalgia (FM) (worse)
- β = −0.068
- axSpA, HRQoL: age (better)
- β = 0.001
- axSpA, HRQoL: university education (better)
- β = 0.014
- pSpA, HRQoL: disease activity (worse)
- β = −0.04
- pSpA, HRQoL: physical function (worse)
- β = −0.054
- PsA, HRQoL: disease activity (worse)
- β = −0.045
- PsA, HRQoL: physical function (worse)
- β = −0.053
- PsA, HRQoL: axial disease (worse)
- β = −0.041
- PsA, HRQoL: female sex (worse)
- β = −0.028
- axSpA, GH: disease activity (worse)
- β = 0.889
- axSpA, GH: physical function (worse)
- β = 0.887
- axSpA, GH: peripheral disease (worse)
- β = 0.564
- axSpA, GH: female sex (worse)
- β = 0.812
- axSpA, GH: FM (worse)
- β = 1.639
- axSpA, GH: age (better)
- β = −0.013
- axSpA, GH: university education (better)
- β = −0.274
- pSpA, GH: physical function (worse)
- β = 1.142
- pSpA, GH: female sex (worse)
- β = 1.060
- pSpA, GH: university education (better)
- β = −0.611
- PsA, GH: disease activity (worse)
- β = 0.703
- PsA, GH: physical function (worse)
- β = 1.025
- PsA, GH: axial involvement (worse)
- β = 0.659
- PsA, GH: female sex (worse)
- β = 0.924
- PsA, GH: FM (worse)
- β = 1.387
- PsA, GH: age (better)
- β = −0.024
- PsA, GH: university education (better)
- β = −0.856
Observational data: associations, not effects.
Original publication
Determinants of health-related quality of life and global functioning and health in axSpA, pSpA and PsA: results from the ASAS-PerSpA study. Rheumatology (Oxford). Published 21 September 2023. doi:10.
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